Reims took an early lead through captain Yunis Abdelhamid's header in the 11th minute. But goals from Raphinha and Damien Da Silva put Rennes in front at the break.
The Argentinian bested Nadal in the Rome Masters quarter-finals last month for his first win against the world number two.
"We executed the tactics and contained them quite well," Wang Siyu noted.
The first 45 minutes were entertaining, but after the break Barca began to look fatigued. Ronald Koeman made several changes, bringing Francisco Trincao, Pedri and Miralem Pjanic into the action, while Sergino Dest made his debut for the injured Jordi Alba. Despite Trincao having a late shot saved, Barca didn't do enough to win, while Sevilla looked happy with a point.
Peng Szu-Chin led Shanghai's charge with 25 points. Li Yingyun and Zhang Zhiting contributed 24 and 21 respectively. Zhang also grabbed 11 rebounds.
While Ajax failed to create any more chances in its hunt for the equalizer, Ramon-Pascal Lundqvist hit the post on the other side. In the final minutes Ajax came close to a goal with both Dusan Tadic and Klaas-Jan Huntelaar hitting the post. The result is the first defeat for Ajax this season after three wins in its first three matches.
Bolivia will field a depleted team for the matches in Sao Paulo on October 9 and La Paz four days later amid a series of controversies affecting the national football scene.
"I'm sure that I can make many layups on the university basketball court, but here, when opponents inflicted huge pressure on me, my chance of doing that will be much lower."
"It's not easy for us to return to court. I always want to say thanks to all medical staff across the country for giving us a safe environment to play. We appreciate it a lot," Wu said.
Colombia will host Venezuela in Barranquilla on October 9 before facing Chile in Santiago four days later in the opening fixtures of the South American zone qualifiers.
Bayern grew into the game as the clock ticked, and Muller's goal was reversed by the video assistant referee before Lewandowski nodded home Serge Gnabry's cross to mark his 100th goal on home soil.